The TIPIN antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to TIPIN. This antibody recognizes Homo Sapiens, and Human antigen. The TIPIN antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress